Siesta-Time Is in the Genes

the growing coat? If so, how and why? Some evidence the ratio of two different forms of FRQ, each of which on its own has the ability to keep time over a different presented by Ringstad and colleagues supports this peripheral localization of endophilin I in the clathrin-temperature range (Liu et al., 1997). In a second example , Drosophila collected from the wild display a poly-coated bud. Perhaps steric hindrance prevents endo-philin from being included inside the coat, and clathrin morphism in a threonine–glycine dipepetide repeat near the middle of the PERIOD (PER) clock protein, and these assembly occurs only after the enzyme is displaced. It may also be efficient to have the reaction leading to subtly different PER forms are better suited to withstand the ranges of temperature found in their environments lipid shape alteration occur at the edge of the growing bud, where the curvature needs to be changed the most. (Sawyer et al., 1997). The latter study suggested a relationship between As the bud grows, what was once the edge (with negative curvature) gradually becomes part of the interior PER protein and temperature regulation. Now, in this issue of Neuron, Majercak et al. (1999) find a connection membrane (with positive curvature)—so having cone-shaped lipids inside no longer makes sense. Do cone-between per RNA, temperature, and siesta-time. per RNA cycles with a peak once every 24 hr. The authors shaped lipids stay at the edge by continually moving laterally toward the edge of the growing coat? Does show that per RNA accumulates to higher levels and at an earlier time in each cycle at 18ЊC compared to 29ЊC. endophilin-mediated lipid modification actually provide the driving force to form appropriately curved membrane Furthermore, they find that this correlates with increased splicing of the intron closest to the 3Ј end of the per 3Ј and clathrin coats? Since the lipid composition of the vesicle membrane is modified during its formation, a UTR at 18ЊC. This is a rapid response: a shift down in temperature increases splicing of this intron, leading to reverse modification must occur elsewhere if equilibrium is to be maintained. Does this reverse modification occur higher per RNA levels within an hour. Majercak et al. (1999) then tested the simple idea after the vesicle fusion event? The pace of investigation in this field guarantees speedy answers to these and that per RNA lacking this intron would mimic the …